Limited dose warfarin throughout pregnancy in patients with mechanical heart valve prosthesis: a meta-analysis
نویسندگان
چکیده
منابع مشابه
Warfarin resistance in a patient with mechanical valve prosthesis.
he term warfarin resistance is usually reserved for patients who require warfarin in excess of 20 mg/day to maintain the International Normalized Ratio (INR) within the therapeutic range. It is usually encountered at the start of therapy, however, it may also occur in patients who have been already on warfarin therapy. Both diet and the co-administration of certain drugs can have a marked effec...
متن کاملA mechanical analysis of the closed Hancock heart valve prosthesis.
In order to obtain mechanical specifications for the design of an artificial leaflet valve prosthesis, a geometrically non-linear numerical model is developed of a closed Hancock leaflet valve prosthesis. In this model, the fibre reinforcement of the leaflet and the viscoelastic properties of frame and leaflets are incorporated. The calculations are primarily restricted to 1/6 part of the valve...
متن کاملClinical and genetic factors associated with warfarin maintenance dose in northern Chinese patients with mechanical heart valve replacement
The effects of genetic variants on warfarin dosing vary among different ethnic groups, especially in the Chinese population. The objective of this study was to recruit patients through a rigorous experimental design and to perform a comprehensive screen to identify gene polymorphisms that may influence warfarin dosing in northern Han Chinese patients with mechanical heart valve replacement. Con...
متن کاملPregnancy outcomes compared in women with mechanical heart valve replacements anticoagulated with warfarin and enoxaparin in pregnancy.
The anticoagulation of choice for mechanical heart valves is the oral anticoagulant warfarin. Warfarin is associated with increased risk of miscarriage, intrauterine fetal deaths and warfarin embryopathy. This longitudical cross-over study of 5 women observed all 5 having livebirths of healthy infants after heparin-managed pregnancies. Their earlier 8 pregnancies had all resulted in perinatal l...
متن کاملRelative Expression of PBMC MicroRNA-133a Analysis in Patients Receiving Warfarin After Mechanical Heart Valve Replacement
Background MicroRNAs (miRNAs) are implicated in various biological processes including anticoagulation. However, the modulation of miRNA by pharmacological intervention such as warfarin treatment in patients receiving warfarin has not been disclosed yet. The aim of this study work was to assess the effect of warfarin drug on expression level of mir-133a-3p in patients with mechanical heart valv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Interactive CardioVascular and Thoracic Surgery
سال: 2014
ISSN: 1569-9293,1569-9285
DOI: 10.1093/icvts/ivu009